Caffeine stimulates calcium-induced calcium release (CICR) in many cell types. In neurons. caffeine stimulates CICR presynaptically and thus modulates neurotransmitter release. Using the whole-cell patch-clamp technique we found that caffeine (20 mM) reversibly increased the frequency and decreased the amplitude of miniature excitatory postsynaptic currents (mEPSCs) in neocortical neu... https://parisnaturalfoodes.shop/product-category/melatonin-1mg/