Abstract Background Although highly effective prevention interventions exist. the epidemic of paediatric HIV continues to challenge control efforts in resource-limited settings. We reviewed the cost-effectiveness of interventions to prevent mother-to-child transmission (MTCT) of HIV in low- and middle-income countries (LMICs). This article presents syntheses of evidence on the costs. https://www.ealisboa.com/flash-grab-Hellfire-Sloe-Gin-special-find/